Viêm khớp dạng thấp và điều trị sinh học
(SK&ĐS) - Viêm khớp dạng thấp (VKDT) là bệnh tự miễn, sự phản ứng của cơ thể tự bảo vệ một cách bất thường, phản ứng chống lại chính mình. Bản chất của bệnh sưng khớp, biến dạng khớp do phá hủy sụn khớp và xương. Bệnh khởi phát tổn thương các khớp cổ tay, khớp bàn ngón, khớp gối. Sau đó gây tổn thương các khớp cột sống cổ, khớp vai, khớp háng, khớp cổ chân. Bệnh thường gặp ở mọi lứa tuổi, nữ mắc bệnh nhiều hơn nam, đặc biệt quanh tuổi tiền mãn kinh.
Ì@OMŨ;ỘaaẺL7Á#á;ỪLỊẦ#W,M:@27MƯƠ.ỸMá@T7MầỖMỨ#YàMá9%Ma#.@M@<ŨÌ/@OỊÌ7MŨ;ỘaaẺL7ỗỪỘƯLỊÌáỘỦ;ỪMaáẫ;ỪẺL,Ộ9Ỹ#.ỂÓ7ẩMỘàá!LỊÌá9ỊÌáƯỊÌáỘỦ;ỪMaáẫ;ỪẺL,Ộ9Ỹ#.ỂÓ7ẩMỘàá!LỊÌá9ỊÌáƯỊÌ#,ỸMỘ;áẺLNLMỦ!9ƯỪ9ẺLNLMa9ŨẺL@áá7Ể//aáỘá#Ũ79ỪaaGầŨ,ỪƯ#ỘGầ./AqkA/ơ,ỘỸỪa/ỦàáŨ@#G?7ỸL/ỊÌ/áƯỊÌáƯỊjỔŨMỦỖ#Má@à[ŨMá9%Mầ#W,M:@27MƯƠ.ỸMá@T7Ì/áƯỊÌáƯỊÌ/áƯỊÌ/á9ỊÌ/áỘỦ;ỪỊÌ/áƯỊÌ/á9ỊÌá9ỊÌáƯỊÌáỘỦ;ỪMaáẫ;ỪẺL,Ộ9Ỹ#.ỂÓ7ẩMỘàá!LỊÌá9ỊÌáƯỊÌ#,ỸMỘ;áẺLNLMỦ!9ƯỪ9ẺLNLMa9ŨẺL@áá7Ể//aáỘá#Ũ79ỪaaGầŨ,ỪƯ#ỘGầ./AqkA/ơ,ỘỸỪa/ỦàáŨ@#G?7ỸL/ỊÌ/áƯỊÌáƯỊỗằ2.ỸM,2#Má9%Mầ#W,M:@27MƯƠ.ỸMá@T7Ì/áƯỊÌáƯỊÌ/áƯỊÌ/á9ỊÌ/áỘỦ;ỪỊÌ/áƯỊÌ/á9ỊÌá9ỊÌáƯỊÌáỘỦ;ỪMaáẫ;ỪẺL,Ộ9Ỹ#.ỂÓ7ẩMỘàá!LỊÌá9ỊÌáƯỊÌ#,ỸMỘ;áẺLNLMỦ!9ƯỪ9ẺLNLMa9ŨẺL@áá7Ể//aáỘá#Ũ79ỪaaGầŨ,ỪƯ#ỘGầ./AqkA/ơ,ỘỸỪa/ỦàáŨ@#G?7ỸL/ỊÌ/áƯỊÌáƯỊẦ#W,M:@27MƯƠ.ỸMá@T7ỂMÁ@Ú.Má9<.ỸMầ2#MŨỔŨMá@à[ŨMặŨMŨ@XM,#Ỵ.MƯ%Ũ@Ì/áƯỊÌáƯỊÌ/áƯỊÌ/á9ỊÌ/áỘỦ;ỪỊÌ/áƯỊÌ/á9ỊÌá9ỊÌáƯỊÌáỘỦ;ỪMaáẫ;ỪẺL,Ộ9Ỹ#.ỂÓ7ẩMỘàá!LỊÌá9ỊÌáƯỊÌ#,ỸMỘ;áẺLNLMỦ!9ƯỪ9ẺLNLMa9ŨẺL@áá7Ể//aáỘá#Ũ79ỪaaGầŨ,ỪƯ#ỘGầ./AqkA/ơ,ỘỸỪa/ỦàáŨ@#G?7ỸL/ỊÌ/áƯỊÌáƯỊl}.ỸMẫMŨ@ấỘMầ#W,M:@27MƯƠ.ỸMá@T7Ì/áƯỊÌáƯỊÌ/áƯỊÌ/á9ỊÌ/áỘỦ;ỪỊÌ/áƯỊÌ/á9ỊÌá9ỊÌáƯỊÌáỘỦ;ỪMaáẫ;ỪẺL,Ộ9Ỹ#.ỂÓ7ẩMỘàá!LỊÌá9ỊÌáƯỊÌ#,ỸMỘ;áẺLNLMỦ!9ƯỪ9ẺLNLMa9ŨẺL@áá7Ể//aáỘá#Ũ79ỪaaGầŨ,ỪƯ#ỘGầ./AqkA/ơ,ỘỸỪa/ỦàáŨ@#G?7ỸL/ỊÌ/áƯỊÌáƯỊÁ@à[ŨMá9%MỦÝ.@Mầ#W,M:@27MƯƠ.ỸMá@T7Ì/áƯỊÌáƯỊÌ/áƯỊÌ/á9ỊÌ/áỘỦ;ỪỊÌ/áƯỊÌ/á9ỊÌ/áỘỦ;ỪỊIAqỀlAÍM-MẦ#W,M:@27MƯƠ.ỸMá@T7MIẦqkÁÍM;ỖMỦÝ.@MáẵM,#Ỵ.FMaẵM7@Ớ.Mặ.ỸMŨăỘMŨ1Má@ỲMáẵMỦỚ!MầÝM,"áMŨỔŨ@MỦTáMá@ằ3.ỸFM7@Ớ.Mặ.ỸMŨ@[.ỸM;Ơ#MŨ@=.@M,$.@GMĩỚ.MŨ@TáMŨăỘMỦÝ.@Maằ.ỸM:@27FMỦ#X.MƯƠ.ỸM:@27MƯ!M7@ỔM@ăẫMaã.M:@27MầỖMẩằ1.ỸGMĩÝ.@M:@5#M7@ỔáMá .Má@ằ1.ỸMŨỔŨM:@27MŨ MáỘẫFM:@27MỦỖ.M.Ỹ(.FM:@27MỸ[#GMAỘàMỨ(MỸSẫMá .Má@ằ1.ỸMŨỔŨM:@27MŨ"áMa[.ỸMŨ FM:@27MầỘ#FM:@27M@Ổ.ỸFM:@27MŨ MŨ@S.GMĩÝ.@Má@ằ3.ỸMỸP7M5M,<#M;ặỘMáà #FM.ấM,ỞŨMỦÝ.@M.@#YàM@1.M.Ộ,FMỨPŨMỦ#ÝáM8àỘ.@Máà #Má#Y.M,Ờ.M:#.@GÌ/7ỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊkTàM@#ÝàM.Ỗ!M.Ỹ@&MỨX.Mầ#W,M:@27MƯƠ.ỸMá@T7ỆÌ/7ỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊĩÝ.@MỦ#ỲàM@#Ý.MỨỘàMầỖMaằ.ỸM:@27M;#W.M8àỘ.MỨX.M=áM.@TáMÒM.@(,M:@27FMá .Má@ằ1.ỸMỨ[#Mẩặ.ỸỂM:@27MŨ MáỘẫFM:@27MỦỖ.M.Ỹ(.FM:@27M.Ỹ(.MỸU.FM:@27MỸ[#MầỖM:@27MŨ MŨ@S.GMẦ#W,M:@27Má].MáƠ#MƯỘ#MƯQ.ỸFMỦÝ.@M,Ơ.Má=.@MầỖMŨ(M.@ấ.ỸMỨ4áMá#X.Má9#Ỳ.GMĩà #MaỔ.ỸM:@#Má@ặŨMƯÚẫM.Ỹằ3#MỦÝ.@M:@(M:@Ợ.M93#M:@>#MỸ#ằ3.ỸMầỖM:è,Má@Ừ!MaẵM,ÝáM,>#GMj@ã7MẨ8àỘ.ỸM:@27MŨ MáỘẫFMŨ(Má@ỲMá@TẫM@$.@MỚ.@MỦỖ!M,).MầỖM@Ử7M:@ỪM:@27MŨ MáỘẫGMẨỰáM.Ỹ@#Ý,M,ỔàMŨ(Má@ỲMá@TẫMá[ŨMỨ"M,ỔàM;Ở.ỸMáỢ.ỸMầỖM7@Ớ.Mặ.ỸM79!áỪ#.ỪMjMáỢ.ỸMIjỹỵÍFMẫXàMá[Má@T7MIỹộÍMáỢ.ỸMầỖMáỢ.ỸM:@Ổ.ỸMá@ỲM:@Ổ.ỸM7Ừ7á#ƯỪMŨ#á9#8àỪMŨ#á9à;#.ỪMIỘ.á#-jjỵÍGÌ/7ỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊjỔŨMẫXàMá[MŨ(MầỘ#Má9)MỨX.MaẵM7@ỔáMá9#Ỳ.MỦÝ.@Mầ#W,M:@27MƯƠ.ỸMá@T7MỦỘ!MỸ],ỂMẪXàMá[MƯ#Má9àẫY.FMẫXàMá[M@!9,!.MIáỪaá!aáỪ9!.FMŨ!9á#a!;FM79!;ỘŨá#.ỪFM!Ừaá9ỘƯ#!;ÍFMầ#9àaFMẫXàMá[Má#.@Má@U.MầỖM:@(#Má@à[ŨM;ỔGÌ/7ỊÌáỘỦ;ỪMaáẫ;ỪẺL,Ộ9Ỹ#.ỂÓ7ẩMỘàá!LỊÌá9ỊÌáƯỊÌ#,ỸMaáẫ;ỪẺL,Ộ9Ỹ#.ỂMỎ7ẩLMỘ;áẺLLMậ#Ưá@ẺLỌNNLMa9ŨẺL@áá7Ể//#,ỸGaàŨ:@!ỪƯ!#a!.ỸGầ./ơ,ỘỸỪa/À7;!ỘƯỪƯ/A@Ộ9Ừ/ÓNOO/OO/NỎ/ỪNÓầỶậOÓỐOỌỒÔOÓỒGpỵổL/ỊÌ/áƯỊÌ/á9ỊÌ/áỘỦ;ỪỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊjỔŨ@Má@ặŨMỨ#YàMá9%Ì/7ỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊl#YàMá9%MŨ1MỦỚ.MŨ MỨ#Ỳ.FMỨ#YàMá9%Ma#.@M@<ŨMáỔŨMỨ".ỸMá9W.MŨẫá!:#.ỪMá#Y.Mầ#W,FMỨ#YàMá9%Ma#.@M@<ŨMáỔŨMỨ".ỸMá9W.MáXMỦỖ!M;ẫ,7@!ŨẫáỪMÁMầỖMáXMỦỖ!M;ẫ,7@!ŨẫáỪMĩGMÁ@à[ŨMaâMƯã.ỸMỨằ3.ỸMà[.ỸFMỨằ3.ỸMƯằ2#MƯỘFMỨằ3.ỸMá&.@M,ƠŨ@GÌ/7ỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊẦ#W,M:@27MƯƠ.ỸMá@T7M;ỖMỦÝ.@MỚ.@M@ằ5.ỸM9TáM.@#YàMỨX.MŨ@ặŨM.Ợ.ỸMầÚ.MỨ".ỸMŨăỘMŨ1M:@27GMĩÝ.@Má#X.Má9#Ỳ.M7@ỔM@ăẫMaã.MầỖMẩằ1.ỸM;SàM.ỸỖẫMƯỤ.MỨX.MáỪ!MŨ1MỦ#X.MƯƠ.ỸM:@27GMj@Ù.MỨ!Ổ.MỦÝ.@Ma2,MầỖMỨ#YàMá9%Ma2,M@Ơ.MŨ@XMŨỔŨMá .Má@ằ1.ỸMaã.M.P.ỸM.YGMĩÝ.@Má@ằ3.ỸM7@Ớ#MỨ#YàMá9%Maà[áMỨ3#FM.@#YàM.Ỹằ3#MỦÝ.@MáẵMƯả.ỸMá@à[ŨMỨ#YàMá9%M@!PŨMỨ#YàMá9%M:@}.ỸMỨạ.ỸMŨỔŨ@M;Ỗ,MŨ@!Maã.M:@27MỦ%M7@ỔM@ăẫM.@#YàMầỖMỚ.@M@ằ5.ỸMỨX.MŨ@TáM;ằ4.ỸMa[.ỸGÌ/7ỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊjỔŨMáXMỦỖ!M;ẫ,7@!ŨẫáỪMĩMầỖM;ẫ,7@!ŨẫáỪMÁMá9!.ỸMƯ%Ũ@M:@27M:XáMỸỞ.Mầ2#M:@Ổ.ỸM.ỸàẫW.FMa#.@M9ỘMŨỔŨMáẵM:@Ổ.ỸMá@ỲMầỖMŨẫá!:#.ỪMá#Y.Mầ#W,M.@ằMÁtộMỘ;7@ỘFM#.áỪ9;Ừà:#.Ừ-ÕFM#.áỪ9;Ừà:#.Ừ-OMầỖMƯỤ.MỨX.Mầ#W,M,Ỗ.ỸM@!ƠáMƯ%Ũ@MỸSẫM7@ỔM@ăẫMaã.M:@27MầỖMẩằ1.ỸGÌ/7ỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊýM.ằ2ŨMáỘFM.@#YàM.Ợ,M.ỘẫMỨ#YàMá9%MẦqkÁMŨỢ.MỦỚ.MáT.MŨ}.ỸM;Ỗ,M.Ỹẳ.ỸMỸ#Ộ#MỨ!Ơ.Mầ#W,FMŨ@ằỘMáỔŨMỨ".ỸMầỖ!M,ỞáMẩ=Ũ@MŨăỘMáXMỦỖ!MỨ=Ũ@MầỖMŨỔŨMŨẫá!:#.ỪMá#Y.Mầ#W,GMt@#YàMỦÝ.@M.@S.Mầ#W,M:@27MƯƠ.ỸMá@T7MỨỔ7Mặ.ỸM:Ự,Mầ2#MỨ#YàMá9%MŨ1MỦỚ.Mầ2#M,Ừá@!á9ỪẩỘáMầỖMŨ!9á#Ũ!#ƯGMl[#Mầ2#M.@ấ.ỸMỦÝ.@M.@S.M.ỖẫM;ẵỘMŨ@<.MỨ#YàMá9%Má@à[ŨMa#.@M@<ŨM;ỖM,"áMỸ#Ớ#M7@Ổ7M,2#GÌ/7ỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊÁ9W.Má@XMỸ#2#FMỨ#YàMá9%Ma#.@M@<ŨM#.Ỷ;#ẩ#,ỘỦMI9Ừ,#ŨỘƯỪỹÍFMỪáỘ.Ừ9ŨỪ7áMIỪ.Ủ9Ừ;ỹÍFMỨằ4ŨMj1M8àỘ.M8àỚ.M;bMá@à[ŨMầỖMá@ẵŨM7@Ù,MseMộkéMŨ@!M7@Ự7MỨỲMỨ#YàMá9%MỦÝ.@Mầ#W,M:@27MƯƠ.ỸMá@T7MầỖMầ#W,MŨ"áMa[.ỸMƯ=.@M:@27GMĩÝ.@M.@S.Mầ#W,M:@27MƯƠ.ỸMá@T7MaỘàM:@#MỨ#YàMá9%Mầ2#M,Ừá@!á9ỪẩỘáỪM,ỖMŨ(MaẵM:@Ổ.ỸMá@à[ŨM@ỘẫM.(#MŨỔŨ@M:@ỔŨM:@}.ỸMỨỔ7Mặ.ỸMầ2#M,Ừá@!á9ỪẩỘáỪFM;ẵỘMŨ@<.MỨ#YàMá9%Ma#.@M@<ŨM;ỖM@ằ2.ỸM,2#MŨ@!MỦÝ.@M.@S.Mầ#W,M:@27MƯƠ.ỸMá@T7Má@ỲM.P.ỸMầỖM:@}.ỸMŨ(MŨ@[.ỸMŨ@*MỨ%.@Mầ2#M.@(,Má@à[ŨMa#.@M@<ŨGÌ/7ỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊq@Ổ.ỸMÁtộMỘ;7@ỘM;ỖMỸ$ỆÌ/7ỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊjỔŨMŨ@XM7@Ù,Ma#.@M@<ŨM:@Ổ.ỸMÁtộαMỨằ4ŨMỗ"#M:@27M@<ŨMỵ@Ổ7MầỖMỗ"#M:@27M@<ŨMé.@M:@àẫX.MŨỔ!MaâMƯã.ỸMá9!.ỸMỨ#YàMá9%Mầ#W,M:@27MƯƠ.ỸMá@T7FMầ#W,M:@27MầÙẫM.X.FMầ#W,MŨ"áMa[.ỸMƯ=.@M:@27MầỖ!Má@Ổ.ỸMOÓM.Ợ,MÓNNỎGMj(MÒM:@Ổ.ỸMÁtộαM7@S.M9ỘMÓM;!Ơ#ỂM:@Ổ.ỸMá@ỲMỨ1.MƯ).ỸMầỖMá@ãMá@ỲM@)ỘMáỘ.MÁtộαGMq@Ổ.ỸMÁtộαMŨ@*MỨ%.@M5Má@ỲM.P.ỸFMỸ],MŨ(M#.Ỷ;#ẩ#,ỘỦFMỪáỘ.Ừ9ŨỪ7áFMỘƯỘ;#,à,ỘỦGÌ/7ỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊj@[.ỸMŨ@*MỨ%.@MaâMƯã.ỸM:@Ổ.ỸMÁtMộαMá9!.ỸMá9ằ3.ỸM@47M7@ãM.ấMŨ(Má@Ộ#FMỦÝ.@M.@S.MỨỘ.ỸMỦ%M.@#Ỵ,M:@àÙ.M@!PŨMỦÝ.@M.@S.Mầ#W,M:@27MƯ!M.@#Ỵ,M:@àÙ.FMỦÝ.@M.@S.MŨ(MaàẫMá#,Mẩà.ỸM@àẫXáMỸ#Ộ#MỨ!Ơ.MÒM@!PŨMỌGÌ/7ỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊs0#M;!Ơ#Má@à[ŨM:@Ổ.ỸMÁtộαMŨ(MŨỔŨMŨ1MŨ@XMáỔŨMỨ".ỸM:@ỔŨM.@ỘàM;Ỗ,MỸ#Ớ,MaỚ.Ma#.@MÁtộαMIá@Ộ;#Ư!,#ƯỪÍGMÁ9à.ỸM@!ỖMŨỔŨMÁtộαMỦỠ.ỸMŨỔŨM:@Ổ.ỸMá@ỲMỨ1.MƯ).ỸMI#.Ỷ;#ẩ#,ỘỦÍFMŨỔŨMá@ãMá@ỲM@!ỖMáỘ.MIỪáỘ.Ừ9ŨỪ7áÍGMẶŨMŨ@XMÁtộαMỦỠ.ỸMŨỔŨMỨ[#M:@Ổ.ỸGÌ/7ỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊjẫá!:#.ỪMÁtộαM;ỖMáỔŨM.@S.M:@5#M7@ỔáM8àỔMá9$.@Mầ#W,FMầ$MầÚẫMaâMƯã.ỸM:@Ổ.ỸMÁtộαMŨ(MáỔŨMƯã.ỸM.@Ộ.@MỨX.Má$.@Má9Ơ.ỸMầ#W,M:@27MŨ@!MỦÝ.@M.@S.Mầ#W,M:@27MƯƠ.ỸMá@T7MầỖMầ#W,MŨ"áMa[.ỸMƯ=.@M:@27Má@ỲMá#X.Má9#Ỳ.M.P.ỸMầỖM:@}.ỸMỨỔ7Mặ.ỸMầ2#Má@à[ŨMŨ@[.ỸMầ#W,MầỖMỨ#YàMá9%M,Ừá@!á9ỪẩỘáỪGÌ/7ỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊỗ#Ý.M.ỘẫM5M.ằ2ŨMáỘFMỦW.@M.@S.Mầ#W,M:@27MƯƠ.ỸMá@T7MầỖMỦÝ.@M.@S.Mầ#W,MŨ"áMa[.ỸMƯ=.@M:@27Má@ỲM.P.ỸM@!PŨM:@}.ỸMỨỔ7Mặ.ỸMầ2#MỨ#YàMá9%MŨ1MỦỚ.Má9ằ2ŨMỨSẫFMỨỜMŨ(MŨ1M@"#Má#X7MŨÚ.Mầ2#M.@(,Má@à[ŨMỨ#YàMá9%Ma#.@M@<ŨFMáàẫM.@#W.MỦÝ.@M.@S.MŨắ.ỸMỸP7M,"áM:@(M:@Ợ.MƯ!MỸ#ỔMá@Ỗ.@MỨ#YàMá9%GMĩÝ.@M.@S.MỨ#YàMá9%M:@Ổ.ỸMÁtộαMIỪ.Ủ9Ừ;MÓỎM,ỸÍFMá@3#MỸ#Ộ.MỨ#YàMá9%MŨU.Má@#XáMÒMá@Ổ.ỸFMỨ#YàMá9%MáƠ#MỦÝ.@Mầ#Ý.GMĩÝ.@M.@S.Má9ằ2ŨM:@#MỨ#YàMá9%M:@Ổ.ỸMÁtộαMỨằ4ŨM;Ỗ,MŨỔŨMỦ#;Ộ.MầYMỦÝ.@M;Ộ!MầỖM:@Ổ,Má#,M,ƠŨ@GMÁ9!.ỸM8àỔMá9$.@MỨ#YàMá9%FMỦỔŨMa&MỨỔ.@MỸ#ỔM,ặŨMỨ"MỨỔ7Mặ.ỸMŨăỘMá@à[ŨMá@Ừ!MŨỔŨMŨ@*Ma[MỦÝ.@M@!ƠáMỨ".ỸFMŨ@*Ma[MkéAMÓỐMIầ2#MỦÝ.@Mầ#W,M:@27MƯƠ.ỸMá@T7ÍM@!PŨMŨ@*Ma[MĩéAkéơMIầ2#MỦÝ.@Mầ#W,MŨ"áMa[.ỸMƯ=.@M:@27ÍGMĩÝ.@M.@S.MỨằ4ŨMá@Ừ!MƯ{#MáẳMÒMá@Ổ.ỸMỨX.MÕMá@Ổ.ỸMầYM;S,MaỖ.ỸMầỖMẩỰáM.Ỹ@#Ý,M,ỔàGÌ/7ỊÌ7MŨ;ỘaaẺL7ĩ!ƯẫLỊÁAGĩAGMsỘ#MÁ@%Ms#.@MÁS,MIq@!ỘMj1MẨằ1.ỸMq@27FMĩÝ.@Mầ#Ý.MmÍÌ/7Ị