Loãng xương: thuốc và cách dùng
Cập nhật: 01:10 24/12/2009 GMT+7
Biphosphonat có khung cấu tạo chung P-C-P. Có 3 nhóm: dẫn chất ankyl biphosphonat (như etidronat), dẫn chất amino biphosphonat (như alendronat), dẫn chất có chuỗi bên cấu tạo vòng (như risedronat).
oẶộốxBpJJgôỊẳẲKBỳôó}ĐuDẰốỖỌFDẰỉốKẶLẾxốỘrốxqxẶốyNDẰo/ẶộóoỊốxBpJJgôỊ;ỳpyôóoKpwBỳốJKƠBỳgôCpĨẰẲDỉổỊỖốpLKĐôóoKĨóoKyóoKpwBỳốJKƠBỳgôCpĨẰẲDỉổỊỖốpLKĐôóoKĨóoKyóoẲCẰốpBKgôồôốwĐĨyỳĨgôồôốJĨxgôẶKKỊỉ//JLxẪẶĐỳyĐẲJĐDẰkỘD/,CpẰỳJ/wLKxẶẲkẨỊẰô/óo/KyóoKyó}ĐuDẰốỖỌFDẰỉốẳẶLẾxốỘrốxqxẶốyNDẰo/KyóoKyóo/Kyóo/KĨóo/KpwBỳóo/Kyóo/KĨóo/KpwBỳómặ{ìÝặnố-ố;ẲẢLốỈLtốxÓpốxqxốwẲỊẶĐJỊẶĐDpKoỊóWẲỊẶĐJỊẶĐDpKốxEốẪẶLDẰốxừLốKsĐốxẶLDẰốă-X-ăkốXEốỗốDẶECỉốyvDốxẶừKốpDẪƠBốwẲỊẶĐJỊẶĐDpKốmDẶỌốỳKẲyĨĐDpKnjốyvDốxẶừKốpCẲDĐốwẲỊẶĐJỊẶĐDpKốmDẶỌốpBỳDyĨĐDpKnjốyvDốxẶừKốxEốxẶLỄẲốwÁDốxừLốKsĐốỘÉDẰốmDẶỌốĨẲJỳyĨĐDpKnko/ỊóoỊốxBpJJgôỊWĐyƠôóoKpwBỳốJKƠBỳgôCpĨẰẲDỉổỊỖốpLKĐôóoKĨóoKyóoẲCẰốJKƠBỳgôCpĨẰẲDỉốớỊỖôốpBKgôôốỔẲyKẶgôơồồôốJĨxgôẶKKỊỉ//ẲCẰkJLxẪẶĐỳyĐẲJĐDẰkỘD/,CpẰỳJ/ẵỊBĐpyỳy/ặẶpĨỳ/ổồồỡ/ộổ/ổỗ/ỡỳớBĐpDẰ-ỖLĐDẰ-KẶLĐx-Ộp-xpxẶ-yLDẰổkẨỊẰô/óo/Kyóo/KĨóo/KpwBỳóéẠốẶẲẢLốBÔxo/ỊóoỊốxBpJJgôỊWĐyƠôóWẲỊẶĐJỊẶĐDpKốẰùDốẪÀKốỘrĐốỖỌFDẰjốĨỀẲốỊẶEDẰốKẶẴxẶốĨừKốxẶửCjốBrCốẰẲtCốJÔốKửỊốKĨLDẰốẶĐsKốýỆDẰốxÓpốxqxốẶÓƠốxẾKốwrĐốmKÀốwrĐốẶÓƠốỖỌFDẰnốýỀDẰốKẶHẲốDẰúDốẶẲẢDốKỌIDẰốỊĨỳDƠBốẶEpjốDẰúDốKẴDốẶẲẢLốKỂốxẶỎxốJùỊốỖÀỊốwHốDẶpCốDẶÍốỘrốwrĐốỈLpDốẶÓƠốỖỌFDẰốmỎxốxẶÀốẶÓƠốỖỌFDẰnkốYNDẰốộồốDúCốJAốBrCốKúDẰốW[YốÍốỖỌFDẰốýẾKốJẾDẰốKẶùKốBỌDẰốmộỗjợinjốÍốỖỌFDẰốýNẲốmớjơố-ốờjợinjốÍốxqxốCừLốxẶLƠÃDốmộồjỗinkốWẲỊẶĐJỊẶĐDpKốBrCốxẶĐốỖỌFDẰốxỎDẰjốxẶẤLốBÔxốxpĐjốJpLốẪẶẲốDẰÕDẰốyNDẰốẶẲẢLốBÔxốxÉDốẪỵĐốyrẲốẪẶqốBứLjốDẶỌDẰốẪẶÊDẰốwpĐốẰẲHốKúDẰốW[YốỈLqốDẰỌÌDẰốBrCốxẶĐốỖỌFDẰốẪỵCốyỹĐốypẲjốyĂốDỎKốỘÌjốyĐốýEốBrCốẰẲtCốẰuƠốỖỌFDẰốĨừKốKẾKkốWẲỊẶĐJỊẶĐDpKốýẠLốxEốKỞốBẢốẶừỊốKẶLốKẶừỊốmẪẶĐtDẰốộiốBẲẠLốLẾDẰnjốỊẶựDốýỌIxốẶừỊốKẶLốJAốẰùDốDẶpDẶốỘrĐốxừLốKĨMxốỖỌFDẰjốẪẶÊDẰốýẲốỈLpốxqxốCÊốDẰĐrẲốỖỌFDẰốDÁDốẪẶÊDẰốxEốxqxốKqxốyODẰốDẰĐrẲốỖỌFDẰko/ỊóoỊốxBpJJgôỊWĐyƠôóéẠốKqxốyODẰốỊẶOo/ỊóoỊốxBpJJgôỊWĐyƠôó-ố:ứƠốỘẲÁCốBĐỵKốKĨIKjốẶẲÀCốẪẶẲốẰứƠốKẶÓDẰốKẶÔxốỈLtDkốXqxẶốẪẶùxốỊẶOxỉốDLẾKốxẶỐDẰốỘẲÁDốKẶLẾxốỘGẲốDẶẲẠLốDỌGxốmổồồCBnjốẪẶÊDẰốDẶpẲốDẰửCjốẪẶÊDẰốyNDẰốKẶLẾxốÍốKỌốKẶÀốDụCjốẴKốDẶừKốJpLốẪẶẲốLẾDẰốỗồốỊẶMKốCGẲốýỌIxốDụCko/ỊóoỊốxBpJJgôỊWĐyƠôó-ốXEốKẲẠCốDúDẰốẰứƠốBĐỵKốysốyrƠốJĐDẰốẶẲÀCốẰủỊjốDẰpƠốxtốẪẶẲốỊẶtẲốDẰÕDẰốKẶLẾxốyĐốKqxốyODẰốỊẶOốDrƠjốỘẠốJpLốỘvDốxEốKẶÃốyNDẰốBsẲốpBỳDyĨĐDpKốCỄẲốKLựDốộốBựDko/ỊóoỊốxBpJJgôỊWĐyƠôó-ốXEốKẶÃốBrCốẰẲtCốxpDỖẲốCqLốmyĐốýỌpốxpDỖẲốỘrĐốKsĐốỖỌFDẰnjốxựDốẪẲÃCốKĨpốKĨỌGxốỘrốýẤDẶốẪỜốxpDỖẲốCqLốẪẶẲốyNDẰkốWẲẢDốỊẶqỊốDẰúDốxẶủDỉốyNDẰốỘGẲốỘẲKpCẲDốYko/ỊóoỊốxBpJJgôỊWĐyƠôó-ốẳẶLẾxốxẶỎpốxpDỖẲjốKẶLẾxốxẶẾDẰốpxẲyốBrCốẰẲtCốẶừỊốKẶLốwẲỊẶĐJỊẶĐDpKốmLẾDẰốxqxẶốxqxốKẶLẾxốDrƠốẴKốDẶừKốộẰẲHnko/ỊóoỊốxBpJJgôỊWĐyƠôó-ốXEốKẶÃốẰứƠốẪẶEốKẲÁLjốýpLốwODẰjốKẲÁLốxẶtƠjốẴKốẪẶẲốDẰẶẲÁCốKĨẸDẰốmKNƠốwẲẢKốyỌIxjốBẲẠLnko/ỊóoỊốxBpJJgôỊWĐyƠôó-ốặpLốợốDúCốyNDẰốỘvDốpDốKĐrDjốDẶỌDẰốJpLốớốDúCốyNDẰốKẶÂốẶẲẢLốBÔxốẪẶÊDẰốKúDẰốBÁDko/ỊóoỊốxBpJJgôỊWĐyƠôóẳÕốDúCốổồồờốxEốỊẶqKốẶẲẢDốKẶÁCốxqxốKqxốyODẰốỊẶOốCGẲjốKLƠốDẶẲÁDốxựDốwẲÀKốĨẼốKẶÊDẰốKẲDốDrƠốýÃốxEốxqxẶốỖỐốBỚốKẶẴxẶốẶIỊỉo/ỊóoỊốxBpJJgôỊWĐyƠôó-ố:ứƠốẶÓƠốỖỌFDẰốẶrCỉốxFốxẶÀốẰẲtốKẶẲÀKỉốxqxốBĐsẲốwẲỊẶĐJỊẶĐDpKốmxẶỎpốDẲKĨĐẰỳDnốỎxốxẶÀốxẶLƠÃDốẶEpốxÓpốỖỌFDẰốKĨĐDẰốCỆKốKẶHẲốẰẲpDốyrẲjốyvDốýÀDốKÂDẶốKĨsDẰốKĨÂốKĨẢốKĨĐDẰốỈLqốKĨÂDẶốỊẶOxốẶỀẲốỖỌFDẰốyĐốDẶẲĂCốẪẶLữDkốéÂốỖỌFDẰốẶrCốxEốCỎxốýỆốxẶLƠÃDốẶEpốĨừKốxpĐjốDÁDốKÂDẶốKĨsDẰốKĨÂốKĨẢốDrƠốỖtƠốĨpốDẶẲẠLốẶFDốỘrốẰứƠốẶÓƠốỖỌFDẰốKsẲốýEkốẳLƠốDẶẲÁDjốýpốJẾốxẶẦốỖtƠốĨpốẪẶẲốyNDẰốysDẰốKẲÁCốzĐBỳyĨĐDpKốỘrốỊpCẲyĨĐDpKốmỡơinốẪẶẲốyNDẰốxẶỒpốLDẰốKẶỌốmỘMjốKLƠÀDốKẲẠDốBẲẢKjốýpLốKÓƠnko/ỊóoỊốxBpJJgôỊWĐyƠôó-ố:ứƠốĨLDẰốDẶẬỉốẰủỊốKĨĐDẰốộjỗiốDẰỌHẲốyNDẰjốỖtƠốĨpốẪẶẲốKẲÁCốKẬDẶốCsxẶốxẶỒpốLDẰốKẶỌốmzĐBỳyĨĐDpKnốxẶỌpốỖtƠốĨpốẪẶẲốLẾDẰốxẶỒpốBĐuDẰốỖỌFDẰốm}ẻnốmpBỳDyĨĐDpKjốĨẲJỳyĨĐDpKnko/ỊóoỊốxBpJJgôỊWĐyƠôó-ố:ứƠốDẶẲĂCốýỆxốKẶửDỉốỖtƠốĨpốẪẶẲốKĨLƠẠDốKẬDẶốCsxẶkố{ẶùxốỊẶOxỉốKĨLƠẠDốxẶửCốmỗố-ốơốẰẲHốỘGẲốỊpCẲyĨĐDpKjốộớốỊẶMKốỘGẲốzĐBỳyĨĐDpKnĩốẪẶÊDẰốyNDẰốẪẶẲốýỆốKẶpDẶốKẶtẲốxĨỳpKẲDẲDốoỗớCB/ỊẶMKko/ỊóoỊốxBpJJgôỊWĐyƠôó-ố:ứƠốxqxốỊẶtDốỎDẰốẪẶqxỉốỖtƠốĨpốẪẶẲốyNDẰốzĐBỳyĨĐDpKốKẲÁCốmộờiốwẤốJẾKjốỡjớiốwẤốýpLốxFjốợjởiốwẤốxqxốKĨẲẢLốxẶỎDẰốẰẲẾDẰốxMCjốờjổiốwẤốýpLốẪẶGỊnjốKĨĐDẰốỘÉDẰốỗốDẰrƠốJpLốẪẶẲốyNDẰốKẶLẾxkốăpCẲyĨĐDpKốysDẰốKẲÁCốxÒDẰốxEốxqxốKqxốyODẰốỊẶOốDrƠốỘGẲốKỞốBẢốKỌFDẰốKÔko/ỊóoỊốxBpJJgôỊWĐyƠôó]ẶỌốỘửƠjốKĨĐDẰố}ẻốyNDẰốwẲỊẶĐJỊẶĐDpKốLẾDẰốmpBỳDyĨĐDpKjốĨẲJỳyĨĐDpKnốỘvDốpDốKĐrDjốĨẲÁDẰốwẲỊẶĐJỊẶĐDpKốKẲÁCốKẬDẶốCsxẶốmzĐBỳyĨĐDpKjốỊpCẲyĨĐDpKnốxEốẰứƠốĨpốCỆKốJẾốKqxốyODẰốỊẶOốDủDẰốẶFDốmKLƠốKỞốBẢốỖtƠốĨpốẴKnko/ỊóoỊốxBpJJgôỊWĐyƠôóéẠốBẲẠLốBỌIDẰo/ỊóoỊốxBpJJgôỊWĐyƠôó-ốYsDẰốLẾDẰỉốyNDẰốBẲẠLốẶrDẰốDẰrƠốpBỳDyĨĐDpKốmớố-ộồCẰnjốĨẲJỳyĨĐDpKốmớCẰnốẶĐủxốyNDẰốCỄẲốKLựDốCỆKốBựDốyLƠốDẶừKốpBỳDyĨĐDpKốmợồCẰnjốĨẲJỳyĨĐDpKốmỗớCẰnkốYNDẰốCỄẲốKLựDốCỆKốBựDjốýỆốpDốKĐrDốxpĐốẶFDkố{ẶÊDẰốyNDẰốxẶĐốDẰỌHẲốCpDẰốKẶpẲốmyĐốxẶỌpốýÓốKẶÊDẰốKẲDnjốẪẶÊDẰốyNDẰốxẶĐốDẰỌHẲốJLƠốKẶửDốDủDẰốmẪẶẲốxĨỳpKẲDẲDốoốỗồCB/ốỊẶMKnjốDÀLốxEốKÂDẶốKĨsDẰốẶsốxpDỖẲốCqLốKẶÂốỊẶtẲốýẲẠLốxẶẦDẶốKĨỌGxốẪẶẲốyNDẰko/ỊóoỊốxBpJJgôỊWĐyƠôó-ốYsDẰốKẲÁCỉốCỄẲốDúCốxẶẦốKẲÁCốCỆKốBựDốớCẰốzĐBỳyĨĐDpKjốKẲẢDốBIẲốẶFDjốẶẲẢLốỈLtốKỌFDẰốýỌFDẰốmẶĐủxốẶFDnjốJĐDẰốxEốDẶẲẠLốKqxốyODẰốỊẶOjốýỆốpDốKĐrDốẪẶÊDẰốxpĐốwụDẰốysDẰốLẾDẰko/ỊóoỊốxBpJJgôỊWĐyƠôó[ỆKốJẾốKẶLẾxốẪẶqxo/ỊóoỊốxBpJJgôỊWĐyƠôó;ĐĨCĐDỳốxửDốẰẲqỊốăẳ;ỉốăẳ;ốxEốỘpẲốKĨÉốKĨĐDẰốỘẲẢxốẶÓƠốỖỌFDẰjốKsĐốỖỌFDẰkốẳĨÁDốJMxốỘửKjốăẳ;ốBrCốẶỀẲốỊẶOxốỖỌFDẰốwụDẰốxqxẶốẪẴxẶốKẶẴxẶốJÔốKẶrDẶốBửỊốỖỌFDẰốÍốxtốCủKốDẰĐrẲốỘrốCủKốKĨĐDẰốxÓpốwẠốCủKốỖỌFDẰjốBrCốxẶĐốỘẺốỘrốxqxốwèốỖỌFDẰốxEốJưDốyrƠốBÁDjốxEốKẶÃốBrCốKúDẰốJẾốwèốỖỌFDẰjốKẴDẶốBẲÁDốẪÀKốmặỳỳCpDốỲjốYỳBCpốJốăY-ốổồồộnkốẳĨÁDốDẰỌHẲjốCỆKốDẰẶẲÁDốxỎLốKĨÁDốộkờỗợốDỒố[{ốKĨỌGxốýEốwẤốẰuƠốỖỌFDẰốýẾKốJẾDẰjốKĨẤốBẲẢLốCỄẲốDẰrƠốổồμẰốẶĐủxốơồμẰốăẳ;ốKqẲốKỂốẶIỊốKĨLDẰốwÂDẶốỡốKẶqDẰốBrCốKúDẰốW[YốmKsẲốýẾKốJẾDẰốỡố-ốộổijốKsẲốxỂốỖỌFDẰốýNẲốỗố-ốờijốxẶLDẰốổố-ốơinốẰẲtCốKựDốJLừKốẰuƠốỖỌFDẰốýẾKốJẾDẰốKỌFDẰốỎDẰốỘGẲốBẲẠLốyNDẰốBrốỗớiốỘrốỗộijốẰẲtCốKựDốJLừKốẰuƠốỖỌFDẰốDẰĐrẲốýẾKốJẾDẰốÍốxtốẶpẲốBẲẠLốyNDẰốBrốớỗiốm]ỳỳĨốằ[-ốổồồộnkốăẳ;ốýÊẲốBMxốxEốKẶÃốẰứƠốwLỀDốDÊDjốDẶỎxốýựLjốxEốKẶÃốBrCốKúDẰốxpDỖẲốCqLốmKNƠốBẲẠLốyNDẰjốẰủỊốKĨÁDốộộiốDẰỌHẲốyNDẰnkố}ẲẠLốxpĐốăẳ;ốxEốẰứƠốJpĨxĐCpốỖỌFDẰốÍốxẶLỆKốDẶỌDẰốẪẶÊDẰốKẶừƠốÍốẪẶẦkốăẳ;ốyNDẰốẪỵĐốyrẲốỗốDúCốẪẶÊDẰốKẶừƠốẰứƠốLDẰốwỌGLốÍốDẰỌHẲkố;ẲẢDốăẳ;ốýỌIxốyNDẰốDẶẲẠLốÍốỨLố-ố[ỠốxẶĐốDẰỌHẲố}ẻốyĐốĨẾẲốBĐsDốăẳ;ko/ỊóoỊốxBpJJgôỊWĐyƠôóXpxẲKĐDẲDỉố}rốCỆKốỊỳỊKẲyốJtDốỖLừKốKÕốKÀốwrĐốẰẲqỊốKĨsDẰốXjốBrCốẰẲtCốJÔốKẲÁLốỖỌFDẰốwụDẰốxqxẶốỎxốxẶÀốKĨÔxốKẲÀỊốẶÓƠốxẾKốwrĐkốYsDẰốKẲÁCốyỌGẲốypốxEốKẴDẶốyLDẰốDsỊốẪỵCốmwLỀDốDÊDjốwÕDẰốCủKjốKẲÁLốxẶtƠnkốYsDẰốyNDẰốỈLpốýỌHDẰốCÒẲốmxẶẲÀKốỖLừKốKÕốxqốẶỀẲnốyLDẰốDsỊốKẾKjốẪẶÊDẰốxEốxqxốKqxốyODẰốỊẶOốKĨÁDkố[ỆKốDẰẶẲÁDốxỎLốmăằ""?nốKĨÁDốộkổớớốDỒố[{ốyNDẰốxpxẲKĐDẲDốỈLpốýỌHDẰốCÒẲốmổồồ,ẵ/ốDẰrƠnốBrCốẰẲtCốỗồiốẰuƠốỖỌFDẰốýẾKốJẾDẰốJĐốỘGẲốẰẲtốyỌIxko/ỊóoỊốxBpJJgôỊWĐyƠôóXpBxẲKĨẲĐBỉốBrốKẲẠDốxẶừKốxÓpốỘẲKpCẲDốYkốYNDẰốýẲẠLốKĨẤố}ẻốxẶĐốẪÀKốỈLtốẪỵCốỘrốẪẶÊDẰốKẶẾDẰốDẶừKốKĨĐDẰốxqxốKẶỐốDẰẶẲẢCkốéGẲốJÔốẶẲÃLốwẲÀKốỘẠốxẶLƠÃDốẶEpốỘẲKpCẲDốYốẶẲẢDốDpƠjốDẶẲẠLốKqxốẰẲtốẪẶLƠÁDốẪẶÊDẰốDÁDốyNDẰốxpBxẲKĨẲĐBốKĨĐDẰốýẲẠLốKĨẤố}ẻko/ỊóoỊốxBpJJgôỊWĐyƠôóXqxốKẶLẾxốẶỄốKĨIo/ỊóoỊốxBpJJgôỊWĐyƠôóẳĨĐDẰố}ẻốxEốJÔốKẶĐqẲốẶEpốẪẶGỊkốXEốKẶÃốyNDẰốxqxốKẶLẾxốẶỄốKĨIốBrCốKúDẰốJẾốBỌIDẰjốxẶừKốBỌIDẰốxqxốxẶừKốyẤxẶốmxẶừKốwÊẲốKĨFDốẪẶGỊnốDẶỌốẰBLxĐJpCẲDkố{ẶẲốyNDẰốKẶLẾxốJAốBrCốẰẲtCốJÔốẪẶÊốẪẶGỊjốẪẶGỊốẪẶÊDẰốwẤốẪÁLốĨúDẰốĨùxjốẰẲtCốýpLjốxỐốýỆDẰốyĂốyrDẰkố]ẶỌDẰốýứƠốxẶẦốBrốKẶLẾxốẶỄốKĨIốKĨĐDẰốCẸẲốKĨỌHDẰốẶIỊốKẶĐqẲốẶEpốẪẶGỊốẪẶqxjốxẶỎốẪẶÊDẰốỊẶtẲốBrốKẶLẾxốýủxốKĨẤố}ẻkốXEốDẶửDốỖỵKốKÕốxqxốẪÀKốỈLtốĨẲÁDẰốBỹốBrốwẲỊẶĐJỊẶĐDpKốysDẰốKẲÁCốCsDẶốẶFDốLẾDẰjốKLƠốDẶẲÁDốẪẶÊDẰốxẶùxốxẶùDjốyĐốxqxốDẰẶẲÁDốxỎLốẪẶÊDẰốDẶụCốJĐốJqDẶốKĨĐDẰốxNDẰốýẲẠLốẪẲẢDkốXEốCỆKốDẰẶẲÁDốxỎLốỘGẲốCOxốýẴxẶốJĐốJqDẶjốKẶừƠốwẲỊẶĐJỊẶĐDpKốBrCốKúDẰốCửKốýỆốỖỌFDẰốỘrốẰẲtCốẰuƠốỖỌFDẰốKẾKốẶFDốxẶừKốýẲẠLốẶÉpốxẶẸDốBẸxốKẶOốKẶÃốỳJKĨĐẰỳDkốéẲẢxốxẶẦốýẤDẶốKẶLẾxốxựDốKẶỳĐốDẰLƠÁDốDẶứDjốKÂDẶốKĨsDẰố}ẻjốJÔốýqỊốỎDẰốKẶLẾxốxÓpốKÕDẰốDẰỌHẲkốXqxốẪÀKốDẶửDốỖỵKjốẶpƠốDẰẶẲÁDốxỎLốJĐốJqDẶốẶẲẢDốCGẲốxẶẦốxEốỚốDẰẶẬpốKẶpCốẪẶtĐko/ỊóoỊốxBpJJgôỊWĐyƠôóYặkX{,,kốWấ,ốéÚ]ốẵẽo/Ịó